ETYM See 1 st Irritant.
To cause to be in a worse state.

1. To displease; to make angry; to affront.
2. To be offensive to; to harm; to pain; to annoy
3. To transgress; to violate; to sin against.

To cause to be annoyed, irritated, or resentful.
To make peevish or resentful; annoy

1. To irritate or anger; to disquiet.
2. To make angry or annoyed by little provocations; to irritate.
3. To make more complex or vexing.