(1921-) US physicist who developed radioimmunoassay (RIA), a technique for detecting minute quantities of hormones present in the blood. It can be used to discover a range of hormones produced in the hypothalamic region of the brain. She shared the Nobel Prize for Physiology or Medicine 1977.
Sussman was born in New York and studied at Hunter College and at the University of Illinois. In the 1940s she started working in the Radioisotope Unit of the Veterans Administration Hospital in the Bronx, New York, with a medical doctor, Sol Berson. When he died 1972, Yalow was appointed director of the laboratory.
To measure the concentration of a natural hormone, a solution containing a known amount of the radioisotope-labeled form of the hormone and its antibody is prepared. When a solution containing the natural hormone is added to the first solution, some of the labeled hormone is displaced from the hormone–antibody complex. The fraction of labeled hormone displaced is proportional to the amount of the natural hormone (which is unknown).
Rosalyn S., 19.7.1921, US-amerik. Physikerin; Arbeiten über radioimmunolog. Methoden; Nobelpreis für Medizin 1977.