Locomotive.

(Spanish) insane. loco disease, kind of nervous disease of cattle, sheep and horses due to their eating loco weed.

ETYM Italian.
(Music) A direction in written or printed music to return to the proper pitch after having played an octave higher.
(Slang) Crazy; out of one's mind.

In music, a term used to counteract previous notation (“8ve”) calling for the performance of music at an octave higher or lower than normal; it indicates that the music is to return to its normal “place” on the stave.

Town in Oklahoma (USA); zip code 73442.

1. To poison with locoweed
2. To make frenzied or crazy