Sinonimi: schizophrenic disorder | schizophrenic psychosis | dementia praecox
Mental disorder, a psychosis of unknown origin, which can lead to profound changes in personality, behavior, and perception, including delusions and hallucinations. It is more common in males and the early-onset form is more severe than when the illness develops in later life. Modern treatment approaches include drugs, family therapy, stress reduction, and rehabilitation.
Schizophrenia implies a severe divorce from reality in the patient's thinking. Although the causes are poorly understood, it is now recognized as an organic disease, associated with structural anomalies in the brain. Canadian researchers 1995 identified a protein in the brain, PSA-NCAM, that plays a part in filtering sensory information. The protein is significantly reduced in the brains of schizophrenics, supporting the idea that schizophrenia occurs when the brain is overwhelmed by sensory information.
There is some evidence that early trauma, either in the womb or during delivery, may play a part in causation. There is also a genetic contribution.
Any of several psychotic disorders characterized by distortions of reality and disturbances of thought and language and withdrawal from social contact; SYN. schizophrenic disorder, schizophrenic psychosis, dementia praecox.
Teško nervno obolenje. Niko stvarno ne zna šta je uzrok šizofrenije. Mnoge teorije govore o poremećaju u sistemima neutrotransmitera. Po jednoj teoriji, previše aktivan neurotransmiter dopamin prekida izvesne neuronske puteve. Novije pretpostavke bave se durigm neurotransmiterskim sistemima, uključujuči glutamat i serotonin.
Po svoj prilici, postoji genetska komponenta. U poslednje vreme sve više naučnika veruje da sitna odstupanja u sastavu masti ćelijskih membrana u velikoj meri remete rad mozga, usled čega se javljaju simptomi šizofrenije.